Eden Hazard squandered the decisive penalty as Stoke City deepened Chelsea manager Jose Mourinho's woes with victory in the English League Cup on Tuesday, while second-tier Sheffield Wednesday stunned Arsenal 3-0.
After Jon Walters put Stoke ahead with a fine 20-yard shot at the Britannia Stadium, Chelsea substitute Loic Remy, on for the injured Diego Costa, lashed home an injury-time equaliser to make the score 1-1. Following a goalless period of extra time, the first nine penalties of the shootout were all scored, only for the out-of-form Hazard to see his tenth spot-kick parried by Stoke goalkeeper Jack Butland.
The Belgian's mishap condemned Mourinho's side to their ninth defeat in all competitions this season and saw the holders exit the tournament in the fourth round.
At Hillsborough, Arsene Wenger's Arsenal were well beaten by Championship side Wednesday and also lost Alex Oxlade-Chamberlain and Theo Walcott to injury in the first half. Ross Wallace put Wednesday ahead after 27 minutes and then teed up Lucas Joao for the hosts' second goal shortly before half-time, with Sam Hutchinson completing victory early in the second period.
Elsewhere, second-tier Hull City defeated in-form Premier League side Leicester City 5-4 on penalties after a 1-1 draw, while Everton also needed penalties to beat Norwich City, 4-3, following another 1-1 draw.